李田
发布时间： 2026-05-25 15:19:17 已阅读：
李田
男，博士，研究员，博士生导师。西南大学蚕桑纺织与生物质科学学院副院长、资源昆虫高效养殖与利用全国重点实验室副主任、微孢子虫感染与防控重庆市重点实验室主任。重庆市昆虫学会理事，重庆市遗传学会理事，重庆市生物信息学会理事，中国兽医协会资源昆虫兽医分会副会长、秘书长。主要从事微孢子虫感染与防控研究，先后主持国家自然科学基金项目5项、重庆市自然科学基金项目1项、西南大学先导计划等校级项目3项、企业横向合作项目1项，建成生物大数据与数据库平台（www.biodb.org），构建发布数据库10余个，在PLoS Pathogens、Virulence、Nucleic Acids Research等期刊发表研究论文90余篇，参编专著和译著3部，获授权国家发明专利4项，获教育部自然科学奖二等奖1项(第三完成人)。
一、教育及工作经历
教育经历
1999.09-2003.06 西南农业大学 动物医学 本科
2001.09-2003.06 西南农业大学 计算机科学与技术 本科
2003.09-2009.06 西南大学 生物化学与分子生物学 博士（硕博连读）
工作经历
2009.07-2014.06 西南大学 讲师
2014.07-2021.06 西南大学 副教授、硕士生导师
2021.07-至今 西南大学 研究员、博士生导师
2023.12-至今 西南大学资源昆虫高效养殖与利用全国重点实验室 副主任
2026.04-至今 西南大学蚕桑纺织与生物质科学学院 副院长
二、代表性科研成果
1.代表性科研项目
(1)国家自然科学基金区域创新发展联合基金重点支持项目, 255万元, 2026 - 2029;
(2)西南大学先导计划项目, 60万元, 2023 - 2026;
(3)国家自然科学基金面上项目, 54万元, 2023 - 2026;
(4)国家自然科学基金面上项目, 62万元, 2018 - 2021;
(5)国家自然科学基金面上项目, 80万元, 2015 - 2018;
(6)教育部中央高校基本业务费创新团队项目, 50万元, 2015 - 2017;
(7)国家自然科学基金青年基金项目 , 20万元, 2010 - 2013;
(8)重庆市自然科学基金一般项目, 3万元, 2010 - 2013;
(9)教育部中央高校基本业务费一般项目, 5万元, 2010 - 2012。
2.代表性科研论文
(1)Ziyun Zou, Yibo Hu, Zhongxia Guan, Jiajing Chen, Qingyao Zhang, Yinze Han, Junyu Zhu, Chunxia Wang, Bing Han, Tian Li*, Zeyang Zhou. Microsporidian Encephalitozoon hellem inhibits host mitophagy by inducing ERAD to degrade BNIP3L. PLOS Pathog. 2026, 22(3):e1014078. doi: 10.1371/journal.ppat.1014078.
(2)Chunxia Wang, Yongzhi Kong, Zishen Tang, Tongyu Luo, Xuanang Yang, Yongjun Zhang, Tian Li*, Zeyang Zhou. Unveiling the conserved mechanism of microsporidian vertical transmission: A comparative study of Nosema infection across host species. Virulence. 2025, 17(1):2609384. doi: 10.1080/21505594.2025.2609384.
(3)Xiaodong Li†, Boyu Meng†, Zhi Zhang, Lijuan Wei, Wei Chang, Yuhong Wang, Kai Zhang, Tian Li*, Kun Lu*. qPrimerDB 2.0: an updated comprehensive gene-specific qPCR primer database for 1172 organisms. Nucleic Acids Res. 2024, gkae684. doi: 10.1093/nar/gkae684.
(4)Chunxia Wang†, Bin Yu†, Xianzhi Meng†, Dan Xia†, Boyan Pei, Xiangyou Tang, Guizheng Zhang, Junhong Wei, Mengxian Long, Jie Chen, Jialing Bao, Chunfeng Li, Guoqing Pan, Zeyang Zhou*, Tian Li*. Microsporidian Nosema bombycis hijacks host vitellogenin and restructures ovariole cells for transovarial transmission. PLOS Pathog. 2023, 19(12):e1011859. doi: 10.1371/journal.ppat.1011859.
(5)Tian Li, Junhong Wei, Guoqing Pan. Advances in the Genetic Manipulation of Nosema bombycis. Exp Suppl. 2022, 114:137-152. doi: 10.1007/978-3-030-93306-7_6.
(6)Jian Luo, Jinzhi Xu, Chaolu Xie, Zuoming Zhao, Junrui Guo, Yuan Wen, Tian Li*, Zeyang Zhou*. Microsporidia promote host mitochondrial fragmentation by modulating DRP1 phosphorylation. Int J Mol Sci. 2022, 23(14), 7746. doi: 10.3390/ijms23147746.
(7)Jinzhi Xu, Jian Luo, Jiajing Chen, Charles R. Vossbrinck, Tian Li* and Zeyang Zhou*. Characterization of the Largest Secretory Protein Family, Ricin B Lectin-like Protein, in Nosema bombycis: Insights into Microsporidian Adaptation to Host. J Fungi (Basel), 2022, 8(6): 551. doi: 10.3390/jof8060551.
(8)Yinze Han, Hailong Gao, Jinzhi Xu, Jian Luo, Bin Yu, Chunxia Wang, Boyan Pei, Jiajing Chen, Bing Han, Tian Li*, Zeyang Zhou. Microsporidian Encephalitozoon hellem secretes EhPTP4 to regulate host endoplasmic reticulum-associated degradation. Acta Microbiologica Sinica, 2022, 62(1): 1-17. doi: 10.13343/j.cnki.wsxb.20210263.
(9)Boyan Pei, Chunxia Wang, Bin Yu, Dan Xia, Tian Li* and Zeyang Zhou*. The First Report on the Transovarial Transmission of Microsporidian Nosema bombycis in Lepidopteran Crop Pests Spodoptera litura and Helicoverpa armigera. Microorganisms. 2021, 9(7): 1442. doi: 10.3390/microorganisms9071442.
(10)Tian Li*,†, Chen Xu†, Jinzhi Xu, Jian Luo, Bin Yu, Xianzhi Meng, Chunfeng Li, Guoqing Pan and Zeyang Zhou*. Proteomic Identification of Bombyx mori Organelles Using the Engineered Ascorbate Peroxidase APEX and Development of Silkworm Organelle Proteome Database (SilkOrganPDB). Int. J. Mol. Sci. 2021, 22(9):5051. doi: 10.3390/ijms22095051.
(11)Jian Luo, Qiang He, Jin-Zhi Xu, Chen Xu, Yin-Ze Han, Hai-Long Gao, Xian-Zhi Meng, Guo-Qing Pan, Tian Li*, Ze-Yang Zhou*. Microsporidia infection upregulates host energy metabolism but maintains ATP homeostasis. J Invertebr Pathol. 2021, 107596.
(12)Yingfei Ruan, Xiaofei Xu, Qiang He, Li Li, Junrui Guo, Jialing Bao, Guoqing Pan, Tian Li* and Zeyang Zhou. The largest meta-analysis on the global prevalence of microsporidia in mammals, avian and water provides insights into the epidemic features of these ubiquitous pathogens. Parasites & Vectors. 2021, 14:186.
(13)Yinze Han, Hailong Gao, Jinzhi Xu, Jian Luo, Bing Han, Jialing Bao, Guoqing Pan, Tian Li*, Zeyang Zhou*. Innate and adaptive immune responses against microsporidia infection in mammals. Front. Microbiol.. 2020, 11:1468.
(14)Qiang He, Jian Luo, Jin-Zhi Xu, Xian-Zhi Meng, Guo-Qing Pan, Tian Li*, Ze-Yang Zhou*. In-vitro cultivation of Nosema bombycis sporoplasms: a method for potential genetic engineering of microsporidia. J Invertebr Pathol. 2020 Jun 6;174:107420. doi: 10.1016/j.jip.2020.107420.
(15)Qiang He†, Jian Luo†, Jin-Zhi Xu, Xian-zhi Meng, Guo-Qing Pan, Tian Li*, Ze-Yang Zhou*. Characterization of Hsp70 gene family provides insight into its functions related to microsporidian proliferation. J Invertebr Pathol. 2020, 107394. doi: 10.1016/j.jip.2020.107394.
(16)Qiang He, Jian Luo, Jin-Zhi Xu, Chun-xia Wang, Xian-zhi Meng, Guo-Qing Pan, Tian Li*, Ze-Yang Zhou*. Morphology and Transcriptome Analysis of Nosema bombycis Sporoplasm and Insights into the Initial Infection of Microsporidia. mSphere. 2020 Feb 12;5(1). pii: e00958-19. doi: 10.1128/mSphere.00958-19.
(17)Tian Li*, Xiao-Fei Xu, Hui-Hui Du, Li Li, Neng-Zhang Li, Ze-Yang Zhou and Yuan-Yi Peng*. PamulDB: a comprehensive genomic resource for the study of human- and animal-pathogenic Pasteurella multocida. Database, 2019, baz025. doi: 10.1093/database/baz025.
(18)Qiang He, Charles R. Vossbrinck, Qiong Yang, Xian-Zhi Meng, Jian Luo, Guo-Qing Pan, Ze-Yang Zhou*, Tian Li*. Evolutionary and functional studies on microsporidian ATP-binding cassettes: Insights into the adaptation of microsporidia to obligated intracellular parasitism. Infect Genet Evol, 2019, 68: 136-144. doi: 10.1016/j.meegid.2018.12.022.
(19)Xian-Zhi Meng, Bo Luo, Xiang-You Tang, Qiang He, Ting-Rong Xiong, Zhuo-Ya Fang, Guoqing Pan, Tian Li*, Ze-Yang Zhou*. Pathological analysis of silkworm infected by two microsporidia Nosema bombycis CQ1 and Vairimorpha necatrix BM. J Invertebr Pathol. 2018, 153: 75-84. doi: 10.1016/j.jip.2017.12.005.
(20)Kun Lu†, Tian Li†, Jian He†, Wei Chang†, Rui Zhang, Miao Liu, Mengna Yu, Yonghai Fan, Jinqi Ma, Wei Sun, Cunmin Qu, Liezhao Liu, Nannan Li, Ying Liang, Rui Wang, Wei Qian, Zhanglin Tang, Xinfu Xu, Bo Lei, Kai Zhang, Jiana Li. qPrimerDB: a thermodynamics-based gene-specific qPCR primer database for 147 organisms. Nucleic Acids Res. 2018, 46(D1):D1229-D1236. doi: 10.1093/nar/gkx725.
(21)Tian Li, Guo-Qing Pan, Charles R. Vossbrinck, Jin-Shan Xu, Chun-Feng Li, Jie Chen, Meng-Xian Long, Ming Yang, Xiao-Fei Xu, Chen Xu, Bettina A. Debrunner-Vossbrinck, Ze-Yang Zhou. SilkPathDB: a comprehensive resource for the study of silkworm pathogens. Database. 2017(1): bax001.
(22)Tian Li, Xiwu Qi, Qiwei Zeng, Zhonghuai Xiang, Ningjia He. MorusDB: A resource for mulberry genomics and genome biology. DATABASE. 2014, bau054, doi: 10.1093/database/bau054.
(23) LI Tian, QI Xiao-Ran, TAO Mei-Lin, LIU Xian-Lin, KANG Ding-Rong, QIN Guo-Wei, PAN Guo-Qing, ZHOU Ze-Yang. A Comparative Genomics Analysis of Secreted Proteins from Four Microsporidia. Science of Sericulture. 2013, 39(3): 0527-0536.
(24)Guoqing Pan*, Jinshan Xu*, Tian Li*, Qingyou Xia, Shao-Lun Liu, Guojie Zhang, Songgang Li, Chunfeng Li, Handeng Liu, Liu Yang, Tie Liu, Xi Zhang, Zhengli Wu, Wei Fan, Xiaoqun Dang, Heng Xiang, Meilin Tao, Yanhong Li, Junhua Hu, Zhi Li, Lipeng Lin, Jie Luo, Lina Geng, LinLing Wang, Mengxia Long, Yongji Wan, Ningjia He, Ze Zhang, Cheng Lu, Patrick J Keeling, Jun Wang, Zhonghuai Xiang and Zeyang Zhou. Comparative genomics of parasitic silkworm microsporidia reveal an association between genome expansion and host adaptation. BMC Genomics. 2013, 14: 186.
(25) LI Tian, LIU Xian-Lin, HAN Bing, QI Xiao-Ran, DANG Xiao-Qun, KANG Ding-Rong, PAN Guo-Qing, ZHOU Ze-Yang. A Genome-wide Prediction and Analysis on Secreted Proteins of Nosema bombycis. Science of Sericulture. 2013, 39(2): 0295-0301.
(26)Tian Li, Xiaoqun Dang, Jinshan Xu, Handeng Liu, Guoqing Pan, Zeyang Zhou. Mitochondrial Pyruvate Dehydrogenase E1 of Nosema bombycis - a Marker in Microsporidian Evolution. Current Zoology. 2009, 55: 423-429.
(27) LI Tian, PAN Guo-Qing, DANG Xiao-Qun, ZHOU Ze-Yang. cDNA Library Construction and EST Analysis of Bombyx mori Silk Gland Heavily Infected byNosema bombycis. Science of Sericulture. 2009, 35(2): 320-327.
(28)Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J, Hou Y, Wu Z, Li G, Pan M, Li C, Shen Y, Lan X, Yuan L, Li T, Xu H, Yang G, et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science. 2004, 306: 1937-1940.
3.出版著作
(1)周泽扬，潘国庆†，李田†，许金山†.《家蚕微孢子虫基因组生物学》. 科学出版社. 2014, ISBN 978-7-03-042451-8. (†副主编).
4.发明专利
(1)专利名称:一种多克隆抗体在制备鉴别微孢子虫试剂中的应用, 专利号:ZL202210747291.5, 授权日期:2023.06.30;
(2)专利名称:一种微孢子虫极管蛋白EcPTP1的重组蛋白及其制备方法和应用, 专利号:ZL202311021755.5, 授权日期:2024.05.04;
(3)专利名称:一种微孢子虫表面抗原EcSSP1的重组蛋白、编码基因和生产方法及应用, 专利号:ZL202310833265.9, 授权日期:2024.04.26;
(4)专利名称:微孢子虫极管蛋白EbPTP2的重组蛋白及其制备方法和应用, 专利号:ZL202410270885.0, 授权日期:2024.03.11;
(5)专利名称:一种靶向 EcSSP1 蛋白的单克隆抗体及其在检测微孢子虫中的应用, 申请号:202510358066.6, 申请日期:2025.03.25;
(6)专利名称:一种抗毕氏肠微孢子虫极管蛋白的单克隆抗体及其制备纯化方法和应用, 申请号:2025113377803, 申请日期:2025.09.18.
5.指导学生获奖
指导研究生获得2024年重庆市大学生创新方法大赛三等奖、第六届中国-东盟留学生创新创业大赛三等奖、第十二届重庆市科慧研究生创新创业大赛三等奖，获第十九届iCAN大学生创新创业大赛重庆赛区选拔赛突出贡献个人、突出贡献组织工作者奖励称号。
三、联系方式
联系地址：西南大学41教（科技大楼）305办公室
邮箱：lit@swu.edu.cn